With such an important question upon us individually regarding #covid vaccines, you better do your research… from ALL SIDES.👇🏼
❓So, what does a world-leading Vaccine expert has to say on the matter?…
👨🏼🔬 Peter Attia, M.D. held an incredibly informative interview with Paul Offit, M.D. – a world renowned expert in virology and vaccine development who actively serves the FDA and CDC in a consultative capacity.
👌🏼Said another way, what Paul doesn’t know about vaccines isn’t worth knowing. Of course, tons of bias, but a strong sense of integrity too.
🌟🌟🌟🌟🌟 I cannot recommend this podcast interview enough!
🎧 Whatever your persuasion and current knowledge, this is essential listening as you consider whether it make sense to YOU to accept these experimental vaccines.
⚠️ To be clear, these two individuals are massive vaccine and medicinal advocates. Due to their lifelong career commitment to the medical establishment, you wouldn’t expect anything less. That said, what they say may surprise you…
They cover so much. You’ll be glad you tuned in.
[Interview was on 5th Nov 2020] Here’s my summary:
- Their belief that Andrew Wakefield is a fraud re the MMR Vaccine causes Autism claim, and their frustration with anti-vax movement
- The only way to know is in “Phase IV” – i.e. roll out the vaccines and see what happens. Especially as trials are under powered to see the effects across all health and age demographics. You cannot predict the side effects in studies…
- As such, aftermarket surveillance will be absolutely critical.
- “I think it’s fair to say there’s going to be a learning curve here. So there has to be real humility I think, as we move forward.” ~Paul Offit
- Other vaccines have taken 50+ years of research and development of Virus and Vaccines, plus several product recalls to get something safe and effective enough – e.g. Polio and Rotavirus vaccines.
- Paul Offit spent 26 years developing a Rotavirus vaccine (50 years of effort in total). It was introduced in the 90’s. It was off the market within 10 months…
- In contrast, we’e only known the genome of SARS CoV2 since January… (10 months)
- Overall timeline and cost of Vaccine Development: To go from preclinical trials in animals all the way to FDA approved vaccines, it usually take 15-20 years and over $1 billion
- How are things moving so quickly? Because govts are covering all the cost and liability – paying for phase 3 trials and paying for mass production without knowing whether the vaccine works (no pharmaceutical company would ever do that)
- Paul Offit, 65, would NOT currently take the vaccine(s) until much more data is available, especially for his age group and health status.
- Peter Attia is glad he is not first in line – happy to see it rolled out to millions before he makes his personal judgement.
- The serious unanswerable questions regarding Safety and Efficacy Paul cannot answer, and the worrying degree of speculation regarding these experimental vaccines
- Covering the Vaccine Types, the Main Companies behind them, and details of the Clinical Trials – (1) Live Attenuated, (2) Purified Protein, (3) replication-defective modified Adenovirus, and (4) mRNA vaccines
- All the Vaccines candidates have pretty much skipped Phase 2 and just gone to Phase 3
- mRNA – First out because they are the easiest to design and produce. The extreme cold temps are due to the instability of mRNA vaccines
- Paul’s concerns with the various Vaccine technologies – including worsening conditions and injuries that only show themselves in mass deployment
- People in the “high risk” group equals 150 million people in the US – half the population!
- Thoughts on Russian and Chinese vaccine efforts and deployment
- Addressing the misunderstanding of waning antibodies, and the need to better understand immune memory and T cells.
- Can we expect genetic drift with SARS CoV2 requiring regular vaccination like flu shots? – Single-stranded RNA viruses tend to be sloppy on replication, causing lots of mutations and drift, but so far the drift has not changed its core functionality or spike protein signature.
- Paul thinks the virus will be more like measles vs Influenza – i.e. the virus should offer lifelong immunity
- With Coronavirus infections, you only produce infectious virus for about a week. But, you can show PCR positive for months afterwards as test is picking up mRNA, not the live virus
- What is an EUA – a permission to use a medical intervention even though there may not be clear data showing that it is safe or effective
- Paul believes the vaccines will almost assuredly be effective for at least a few months, and in the worst-case scenario, you could give a booster dose to extend the immunity period
- Paul believes two months of data should be sufficient to identify if there are risks of serious side effects.
- Issue with replication-defective Adenovirus vaccines (e.g. AZ/Oxford vaccine) – potential for serious side effects is greater as you have to give high amounts of virus to get enough to make the desired protein (~10 billion virus particles per dose)
- AZ/Oxford Vaccine – there have been two clinical holds, both because of neurological issues. The first was so-called undiagnosed multiple sclerosis. The second was transverse myelitis — an inflammation of the segment of the spinal cord. “It was adjudicated to be likely to be coincidental and not causal, but it does worry you a little bit that, because it certainly was a statistical bizarity”
- Taking a guess, Paul thinks the Novovax (purified protein with adjuvants) will be better for older people.
- Should we mandate the vaccine for hospital workers? – Paul says NO. “One, we won’t have enough vaccines to make this happen. Two, I think that with the novel vaccine strategy like mRNA, or these replication-defective viruses, I don’t think you really can fairly mandate that, you might need to wait and see.”
- “There’s going to be plenty of people who are going to be perfectly willing to take these vaccines, and then we’ll have a few million doses out there, and we’ll have a sense of things.”
- Vaccine manufacturers will be immunising the THEIR CONTROL GROUP as a “thank you”, effectively ending their clinical trial early. This is a real problem.
- Should Children be vaccinated? – Children, which represent 26% of the population, are less likely to be infected, and they are usually less severely infected (only accounting for about 0.08% of the deaths). But, Paul thinks they should be vaccinated…
- The failed RSV Vaccine effort – a long-standing effort, that has failed due to technical difficulties. RSV is a big contributor to pneumonia and deaths, killing thousands annually and effecting children. Children who got that vaccine did WORSE. Vaccinated children who got exposed to the wild virus were more likely to develop pneumonia and be hospitalised than unvaccinated children.
- RSV relevance to SARS CoV2 – RSV and measles viruses have a fusion protein just like SARS-CoV-2 that caused worse outcomes with vaccines. “That actually is one of the safety things I am worried about with the COVID-19 vaccines”
- How you should never try to fight a Fever – it’s the ideal situation for your immune system to mount a healthy response.
- THE (APPLE) PODCAST INTERVIEW: https://podcasts.apple.com/gb/podcast/the-peter-attia-drive/id1400828889?i=1000498811012
- EXTENSIVE SHOW NOTES & INLINE PLAYER: https://peterattiamd.com/pauloffit/
Enjoyed the read?